Applications listed below support MPTCP natively since the version that is mentioned. Please note that other apps can be forced to use it by following these instructions.

Linux apps

Name	Version	How to use
Apache HTTP Server	2.5.1	Listen 80 options=multipathtcp or ProxyPass multipathtcp=On
Apache Traffic Server	9.2.4	server_ports: <port> mptcp
cURL	8.9.0	--mptcp
dae	v0.8.0	global { mptcp: true }
Envoy	1.21.0	"enable_mptcp": "true" (listening config)
HAProxy	3.1.0	mptcp{,4,6}@<address>
Lighttpd 1.4	1.4.76	server.feature-flags = ( "server.network-mptcp" => "enable" )
QEmu	6.1	<ip>:<port>,mptcp
Shadowsocks libev	v3.3.6	--mptcp
Shadowsocks Rust	v1.16.0	--mptcp
SystemD	v257	SocketProtocol=mptcp ([Socket] section)
v2ray-core	v5.17.0	"mptcp": true

Tools

Name	Version	Comment
pTCPDump	v0.24.0	Can decode MPTCP options in TCP packets
Syzkaller	Feb 2020	Can exercise MPTCP sockets and Netlink APIs
TCPDump	4.5.0	Can decode MPTCP options in TCP packets
Wireshark	4.2.4	Can decode and filter MPTCP options

MacOS apps

Name	Version	How to use
iperf3-darwin	11.0	--apple-multipathsvc
SSH	OpenSSH-281.40.2	applemultipath option
Shellfish	?	Settings / Advanced / 🌍 Multipath TCP

iOS apps

Name	Version	How to use
Apple Maps	>= iOS 13	Enabled by default
Apple Music	>= iOS 13	Enabled by default
Siri	>= iOS 7	Enabled by default
VLC	v4.0	Enabled by default

Misc.

Name	Version
Open MPTCP Router	v0.60

Add native MPTCP support

Do not hesitate to add native MPTCP support in more apps! For some ideas, feel free to look at this spreadsheet.

Others?

Please open a new pull request or an issue if you know any other apps with a community of users and supporting MPTCP natively.